引用本文:
Wei Fan, Lei Chen, Li Hai, Yong Wu. New method in synthesizing an optical active intermediate for (R,R)-formoterol[J]. Chinese Chemical Letters,
2008, 19(3): 279-280.
doi:
10.1016/j.cclet.2008.01.012
Citation: Wei Fan, Lei Chen, Li Hai, Yong Wu. New method in synthesizing an optical active intermediate for (R,R)-formoterol[J]. Chinese Chemical Letters, 2008, 19(3): 279-280. doi: 10.1016/j.cclet.2008.01.012
Citation: Wei Fan, Lei Chen, Li Hai, Yong Wu. New method in synthesizing an optical active intermediate for (R,R)-formoterol[J]. Chinese Chemical Letters, 2008, 19(3): 279-280. doi: 10.1016/j.cclet.2008.01.012
New method in synthesizing an optical active intermediate for (R,R)-formoterol
摘要:
(R)-1-(4-Methoxyphenyl) propan-2-amine 2a, an optical active intermediate for (R,R)-formoterol, was synthesized from D-alanine in 65% overall yield by using a simple route, which contained protecting amino group, cyclization, coupling with Grignard reagent, reduction and deprotection.
English
New method in synthesizing an optical active intermediate for (R,R)-formoterol
Abstract:
(R)-1-(4-Methoxyphenyl) propan-2-amine 2a, an optical active intermediate for (R,R)-formoterol, was synthesized from D-alanine in 65% overall yield by using a simple route, which contained protecting amino group, cyclization, coupling with Grignard reagent, reduction and deprotection.
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Key words:
- (R)-1-(4-Methoxyphenyl)propan-2-amine
- / Formoterol
- / Intermediate
- / Synthesis
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