引用本文:
Qin Zhang, Yao Fu, Hao Wei Wang, Tao Gong, Yong Qin, Zhi Rong Zhang. Synthesis and cytotoxic activity of novel curcumin analogues[J]. Chinese Chemical Letters,
2008, 19(3): 281-285.
doi:
10.1016/j.cclet.2007.12.035
Citation: Qin Zhang, Yao Fu, Hao Wei Wang, Tao Gong, Yong Qin, Zhi Rong Zhang. Synthesis and cytotoxic activity of novel curcumin analogues[J]. Chinese Chemical Letters, 2008, 19(3): 281-285. doi: 10.1016/j.cclet.2007.12.035
Citation: Qin Zhang, Yao Fu, Hao Wei Wang, Tao Gong, Yong Qin, Zhi Rong Zhang. Synthesis and cytotoxic activity of novel curcumin analogues[J]. Chinese Chemical Letters, 2008, 19(3): 281-285. doi: 10.1016/j.cclet.2007.12.035
Synthesis and cytotoxic activity of novel curcumin analogues
摘要:
Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized. Their structures were confirmed by NMR and HRMS spectrum. Their cytotoxic activities against six tumor cell lines were tested by the standard MTT assay in vitro. The results indicated that four analogues (1A-1C, 1E) with solubilizing moieties showed selective potent cytotoxicity against HepG2, HeLa and CT26 cell lines, and analogue 1A and 1C exhibited more potent cytotoxicity than curcumin against CT26 cell line. It was suggested that introduction of appropriate substituents to 4-position of phenyl group might be a potential option for structural modification of curcumin.
English
Synthesis and cytotoxic activity of novel curcumin analogues
Abstract:
Five novel curcumin analogues bearing different substituents at 4-position of phenyl group were synthesized. Their structures were confirmed by NMR and HRMS spectrum. Their cytotoxic activities against six tumor cell lines were tested by the standard MTT assay in vitro. The results indicated that four analogues (1A-1C, 1E) with solubilizing moieties showed selective potent cytotoxicity against HepG2, HeLa and CT26 cell lines, and analogue 1A and 1C exhibited more potent cytotoxicity than curcumin against CT26 cell line. It was suggested that introduction of appropriate substituents to 4-position of phenyl group might be a potential option for structural modification of curcumin.
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Key words:
- Curcumin analogues
- / Synthesis
- / Cytotoxic activity
- / Anti-tumor activity
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