引用本文:
Shu Rong Ban, Cong Wei Niu, Wen Bin Chen, Zhi Hong Yu, Si Wu, Chen Wang, Zhen Xi. Study on the bioactivity changes of hydroxylated sulfonylureas derivatives:A possible metabolism[J]. Chinese Chemical Letters,
2007, 18(2): 205-208.
doi:
10.1016/j.cclet.2006.12.012
Citation: Shu Rong Ban, Cong Wei Niu, Wen Bin Chen, Zhi Hong Yu, Si Wu, Chen Wang, Zhen Xi. Study on the bioactivity changes of hydroxylated sulfonylureas derivatives:A possible metabolism[J]. Chinese Chemical Letters, 2007, 18(2): 205-208. doi: 10.1016/j.cclet.2006.12.012
Citation: Shu Rong Ban, Cong Wei Niu, Wen Bin Chen, Zhi Hong Yu, Si Wu, Chen Wang, Zhen Xi. Study on the bioactivity changes of hydroxylated sulfonylureas derivatives:A possible metabolism[J]. Chinese Chemical Letters, 2007, 18(2): 205-208. doi: 10.1016/j.cclet.2006.12.012
Study on the bioactivity changes of hydroxylated sulfonylureas derivatives:A possible metabolism
摘要:
Some new sulfonylureas and their hydroxylation products had been synthesized from 2-amino-4-methylpyrimidine. Their bioactivities against E. Coli AHAS Ⅱ in vitro were tested and the results indicated that the hydroxylation decreased the inhibition activities of sulfonylureas significantly. Subsequently herbicidal tests against stem-growth of barnyard grass and root-growth of rape confirmed the above conclusion. The preliminary molecular docking studies were also carried out to investigate the binding modes of non-hydroxylated and hydroxylated sulfonylureas with AHAS.
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关键词:
- Sulfonylureas
- / Metabolism
- / Hydroxylation
- / E.coli AHASⅡ
- / Molecular docking
English
Study on the bioactivity changes of hydroxylated sulfonylureas derivatives:A possible metabolism
Abstract:
Some new sulfonylureas and their hydroxylation products had been synthesized from 2-amino-4-methylpyrimidine. Their bioactivities against E. Coli AHAS Ⅱ in vitro were tested and the results indicated that the hydroxylation decreased the inhibition activities of sulfonylureas significantly. Subsequently herbicidal tests against stem-growth of barnyard grass and root-growth of rape confirmed the above conclusion. The preliminary molecular docking studies were also carried out to investigate the binding modes of non-hydroxylated and hydroxylated sulfonylureas with AHAS.
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Key words:
- Sulfonylureas
- / Metabolism
- / Hydroxylation
- / E.coli AHASⅡ
- / Molecular docking
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