Particle-collision and porogen-leaching technique to fabricate polymeric porous scaffolds with microscale roughness of interior surfaces

Zhen Pan Ze-hua Qu Zheng Zhang Rong Peng Ce Yan Jian-dong Ding

Citation:  Zhen Pan, Ze-hua Qu, Zheng Zhang, Rong Peng, Ce Yan, Jian-dong Ding. Particle-collision and porogen-leaching technique to fabricate polymeric porous scaffolds with microscale roughness of interior surfaces[J]. Chinese Journal of Polymer Science, 2013, 31(5): 737-747. doi: 10.1007/s10118-013-1264-1 shu

Particle-collision and porogen-leaching technique to fabricate polymeric porous scaffolds with microscale roughness of interior surfaces

    通讯作者: Jian-dong Ding,
  • 基金项目:

    This work was financially supported by Chinese Ministry of Science and Technology (973 programs Nos. 2009CB930000 and 2011CB606203), and NSF of China (Nos. 21034002, 91127028 and 51273046).

摘要: A facile technique is herein reported to fabricate three-dimensional (3D) polymeric porous scaffolds with interior surfaces of a topographic microstructure favorable for cell adhesion. As demonstration, a well-known biodegradable polymer poly(lactide-co-glycolide) (PLGA) was employed as matrix. Under the porogen-leaching strategy, the large and soft porogens of paraffin were modified by colliding with small and hard salt particles, which generated micropits on the surfaces of paraffin spheres. The eventual PLGA scaffolds after leaching the modified porogens had thus interior surfaces of microscale roughness imprinted by those micropits. The microrough scaffolds were confirmed to benefit adhesion of bone marrow stromal cells (BMSCs) of rats and meanwhile not to hamper the proliferation and osteogenic differentiation of the cells. The insight and technique might be helpful for biomaterial designing in tissue engineering and regenerative medicine.

English


    1. [1]

      Langer, R. and Vacanti, J. P., Science, 1993, 260: 920[2]Karageorgiou, V. and Kaplan, D[J]., Biomaterials.2005, 26(27):5474-[3]Wang, W., Li, D., Wang, M.-c., Li, Y.-l. and Gao, C.-y., Chinese. J. Polym. Sci., 2011, 29(2): 233[4]Ke, J. H., Wang, Z. K., Li, Y. Z., Hu, Q. L. and Feng, J., Chinese. J. Polym. Sci., 2012, 30(3): 436[5]Jiao, Y. P. and Cui, F. Z., Biomed. Mater., 2007, 2(4): R24[6]Zhang, C., Hu, Y. Y., Cui, F. Z., Zhang, S. M. and Ruan, D. K., Biomed. Mater., 2006, 1(2): 56[7]Curran, J. M., Chen, R[J].and Hunt, J. A., Biomaterials.2005, 26(34):7057-[8]Benoit, D. S. W., Schwartz, M. P., Durney, A. R. and Anseth, K. S., Nature Mater., 2008, 7(10): 816[9]Huang, J. H., Grater, S. V., Corbellinl, F., Rinck, S., Bock, E., Kemkemer, R., Kessler, H., Ding, J. D. and Spatz, J. P., Nano Lett., 2009, 9(3): 1111[10]Zhang, Z., Lai, Y. X., Yu, L. and Ding, J. D., Biomaterials, 2010, 31(31): 7873[11]Tang, J., Peng, R[J].and Ding, J. D., Biomaterials.2010, 31(9):2470-[12]Haque, A., Hexig, B., Meng, Q., Hossain, S., Nagaoka, M. and Akaike, T., Biomaterials, 2011, 32(8): 2032[13]Yan, C., Sun, J[J].and Ding, J., Biomaterials.2011, 32(16):3931-[14]Peng, R., Yao, X. and Ding, J., Biomaterials, 2011, 32(32): 8045[15]Chung, S., Gamcsik, M[J].P. and King, M. W., Biomed. Mater.2011, 6(4):045001-[16]Zhao, Y. and Ding, J[J]., Chinese. Sci. Bull.2012, 57(2-3):234-[17]Flemming, R. G., Murphy, C. J., Abrams, G. A., Goodman, S. L. and Nealey, P. F., Biomaterials, 1999, 20(6): 573[18]Mata, A., Boehm, C[J]., Fleischman, A. J., Muschler, G. and Roy, S., J. Biomed. Mater. Res.2002, 62(4):499-[19]Berry, C. C., Campbell, G., Spadiccino, A., Robertson, M. and Curtis, A. S. G., Biomaterials, 2004, 25(26): 5781[20]Wan, Y. Q., Wang, Y., Liu, Z. M., Qu, X., Han, B. X., Bei, J. Z. and Wang, S. G., Biomaterials, 2005, 26(21): 4453[21]Khademhosseini, A., Langer, R[J]., Borenstein, J. and Vacanti, J. P., Proc. Natl Acad. Sci. USA.2006, 103(8):2480-[22]Charest, J. L., Eliason, M. T., Garcia, A. J. and King, W. P., Biomaterials, 2006, 27(11): 2487[23]Teixeira, A. I., McKie, G. A., Foley, J. D., Berticsc, P. J., Nealey, P. F. and Murphy, C. J., Biomaterials, 2006, 27(21): 3945[24]Sarkar, S., Lee, G. Y., Wong, J. Y. and Desai, T. A., Biomaterials, 2006, 27(27): 4775[25]Bettinger, C. J., Langer, R[J].and Borenstein, J. T., Angew. Chem. Int. Edit.2009, 48(30):5406-[26]Mata, A., Kim, E. J., Boehm, C. A., Fleischman, A. J., Muschler, G. F. and Roy, S., Biomaterials, 2009, 30(27): 4610[27]Yao, L., Wang, S. G., Cui, W. J., Sherlock, R., O'Connell, C., Damodaran, G., Gorman, A., Windebank, A. and Pandit, A., Acta Biomater., 2009, 5(2): 580[28]Ghibaudo, M., Trichet, L., Le Digabel, J., Richert, A., Hersen, P. and Ladoux, B., Biophys. J., 2009, 97(1): 357[29]Zorlutuna, P., Elsheikh, A[J].and Hasirci, V., Biomacromolecules.2009, 10(4):814-[30]Schulte, V. A., Diez, M., Moeller, M. and Lensen, M. C., Biomacromolecules, 2009, 10(10): 2795[31]Kantawong, F., Burgess, K. E. V., Jayawardena, K., Hart, A., Burchmore, R. J., Gadegaard, N., Oreffo, R. O. C. and Dalby, M. J., Biomaterials, 2009, 30(27): 4723[32]Kim, E. J., Boehm, C. A., Mata, A., Fleischman, A. J., Muschler, G. F. and Roy, S., Acta Biomater., 2010, 6(1): 160[33]Schulte, V. A., Diez, M., Hu, Y., Moeller, M. and Lensen, M. C., Biomacromolecules, 2010, 11(12): 3375[34]Tanaka, M..[J]. Biochim Biophys Acta.2011,1810:251-[35]Lopez-Alvarez, M., Pereiro, I., Serra, J., de Carlos, A. and Gonzalez, P., Biomed. Mater., 2011, 6(4): 045012[36]Pan, Z., Yan, C., Peng, R., Zhao, Y., He, Y. and Ding, J., Biomaterials, 2012, 33(6): 1730[37]Qu, Z. and Ding, J[J]., Chinese. J. Chem.2012, 30(10):2257-[38]Ishaug, S. L., Crane, G. M., Miller, M. J., Yasko, A. W., Yaszemski, M. J. and Mikos, A. G., J. Biomed. Mater. Res., 1997, 36(1): 17[39]Ma, P. X. and Choi, J[J].W., T1 Eng.2001, 7(1):23-[40]Wu, L. B. and Ding, J[J].D., Biomaterials.2004, 25(27):5821-[41]Safinia, L., Wilson, K[J]., Mantalaris, A. and Bismarck, A., Macromol. Biosci.2007, 7(3):315-[42]Shen, H., Hu, X. X., Bei, J. Z. and Wang, S. G., Biomaterials, 2008, 29(15): 2388[43]Liu, Y. J., Jiang, H[J].L., Li, Y. and Zhu, K. J., Chinese. J. Polym. Sci.2008, 26(1):63-[44]Pan, Z. and Ding, J[J]., Interface Focus.2012, 2(3):366-[45]Wu, L. B., Zhang, H., Zhang, J. C. and Ding, J. D., Tissue Eng., 2005, 11(7-8): 1105[46]Wu, L. B. and Ding, J[J].D., J. Biomed. Mater. Res. Part A.2005, 75A(4):767-[47]Reignier, J. and Huneault, M[J].A., Polymer.2006, 47(13):4703-[48]Odelius, K., Hoglund, A., Kumar, S., Hakkarainen, M., Ghosh, A. K., Bhatnagar, N. and Albertsson, A. C., Biomacromolecules, 2011, 12(4): 1250[49]Ma, Z. W., Gao, C[J].Y., Gong, Y. H. and Shen, J. C., J. Biomed. Mater. Res. Part B-Applied biomat.2003, 67B(1):610-[50]Zhang, J. C., Wu, L. B., Jing, D. Y. and Ding, J. D., Polymer, 2005, 46(13): 4979[51]Murphy, W. L., Dennis, R. G., Kileny, J. L. and Mooney, D. J., Tissue Eng., 2002, 8(1): 43[52]Shi, G. X., Wang, S. G. and Bei, J. Z., J. Funct. Polym., 2001, 14: 7[53]McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K. and Chen, C. S., Dev. Cell, 2004, 6(4): 483[54]Peng, R., Yao, X., Cao, B., Tang, J. and Ding, J., Biomaterials, 2012, 33(26): 6008[55]Wang, Z., Zhang, Z., Zhang, J. C., She, Z. J. and Ding, J. D., Chinese. Sci. Bull., 2009, 54(17): 2968[56]Goldstein, A. S., Juarez, T. M., Helmke, C. D., Gustin, M. C. and Mikos, A. G., Biomaterials, 2001, 22(11): 1279[57]Moroni, L. and Lee, L[J].P., J. Biomed. Mater. Res. Part A.2009, 88A(3):644-[58]Hollister, S. J., Adv. Mater., 2009, 21(32-33): 3330

  • 加载中
计量
  • PDF下载量:  0
  • 文章访问数:  1137
  • HTML全文浏览量:  56
文章相关
  • 发布日期:  2013-05-05
  • 收稿日期:  2012-11-26
  • 修回日期:  2012-12-20
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

/

返回文章