引用本文:
Juan Fang WU, Ling Xin CHEN, Guo An LUO, Yong Suo LIU, Yi Ming WANG, Zhi Hong JIANG. Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules[J]. Chinese Chemical Letters,
2006, 17(3): 383-386.
Citation: Juan Fang WU, Ling Xin CHEN, Guo An LUO, Yong Suo LIU, Yi Ming WANG, Zhi Hong JIANG. Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules[J]. Chinese Chemical Letters, 2006, 17(3): 383-386.
Citation: Juan Fang WU, Ling Xin CHEN, Guo An LUO, Yong Suo LIU, Yi Ming WANG, Zhi Hong JIANG. Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules[J]. Chinese Chemical Letters, 2006, 17(3): 383-386.
Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules
摘要:
Two 17-mer dsDNA with different sequence characteristics were designed to investigate the binding characteristics of berberine, an anticancer drug with uncertain binding mode, and Hoechst 33258, a model DNA minor groove binder, with dsDNA, respectively by the capillary zone electrophoresis (CZE). Kenndler model analysis revealed that Hoechst 33258 exhibited intermediate affinity with dsDNA, while there was only low affinity and some weak binding preference for AATT-containing to GGCC-containing dsDNA for berberine.
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关键词:
- Capillary zone electrophoresis
- / interaction
- / berberine
- / Hoechst 33258
- / DNA
English
Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules
Abstract:
Two 17-mer dsDNA with different sequence characteristics were designed to investigate the binding characteristics of berberine, an anticancer drug with uncertain binding mode, and Hoechst 33258, a model DNA minor groove binder, with dsDNA, respectively by the capillary zone electrophoresis (CZE). Kenndler model analysis revealed that Hoechst 33258 exhibited intermediate affinity with dsDNA, while there was only low affinity and some weak binding preference for AATT-containing to GGCC-containing dsDNA for berberine.
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Key words:
- Capillary zone electrophoresis
- / interaction
- / berberine
- / Hoechst 33258
- / DNA
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