引用本文:
Shang Zhong LIU, Qing Xiao LI. Photoaffinity Probe Candidates for Gamma-aminobutyric Acid (GABAA)-Gated Chloride Channel[J]. Chinese Chemical Letters,
2004, 15(7): 771-773.
Citation: Shang Zhong LIU, Qing Xiao LI. Photoaffinity Probe Candidates for Gamma-aminobutyric Acid (GABAA)-Gated Chloride Channel[J]. Chinese Chemical Letters, 2004, 15(7): 771-773.
Citation: Shang Zhong LIU, Qing Xiao LI. Photoaffinity Probe Candidates for Gamma-aminobutyric Acid (GABAA)-Gated Chloride Channel[J]. Chinese Chemical Letters, 2004, 15(7): 771-773.
Photoaffinity Probe Candidates for Gamma-aminobutyric Acid (GABAA)-Gated Chloride Channel
摘要:
New photoaffinity ligand candidates were synthesized based on 5-t-butyl-2-(4-(substituted-ethynyl)phenyl)-1, 3-dithiane for the noncompetitive blocker site on the gamma-aminobutyric acid-gated chloride channel. Their half-maximal inhibition concentrations ranged from 4 to 32 nmol/L as measured by 4'-ethynyl-4-n-[2,3-3H2]-propylbicycloorthobenzoate (3H EBOB) assay.
English
Photoaffinity Probe Candidates for Gamma-aminobutyric Acid (GABAA)-Gated Chloride Channel
Abstract:
New photoaffinity ligand candidates were synthesized based on 5-t-butyl-2-(4-(substituted-ethynyl)phenyl)-1, 3-dithiane for the noncompetitive blocker site on the gamma-aminobutyric acid-gated chloride channel. Their half-maximal inhibition concentrations ranged from 4 to 32 nmol/L as measured by 4'-ethynyl-4-n-[2,3-3H2]-propylbicycloorthobenzoate (3H EBOB) assay.
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Key words:
- Photoaffinity labeling
- / GABAA receptor
- / 1,3-dithianes
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