引用本文:
Bin YANG, Hou Li JIANG, Zhen Kai DING, Qi Kai ZHANG. Secondary Structure in Solution of an Analog of Salmon Calcitonin:[Val1, Ala7]sCT[J]. Chinese Chemical Letters,
1999, 10(7): 555-558.
Citation: Bin YANG, Hou Li JIANG, Zhen Kai DING, Qi Kai ZHANG. Secondary Structure in Solution of an Analog of Salmon Calcitonin:[Val1, Ala7]sCT[J]. Chinese Chemical Letters, 1999, 10(7): 555-558.
Citation: Bin YANG, Hou Li JIANG, Zhen Kai DING, Qi Kai ZHANG. Secondary Structure in Solution of an Analog of Salmon Calcitonin:[Val1, Ala7]sCT[J]. Chinese Chemical Letters, 1999, 10(7): 555-558.
Secondary Structure in Solution of an Analog of Salmon Calcitonin:[Val1, Ala7]sCT
摘要:
Secondary structure of [Val1, Ala7]sCT, an analog of salmon caleitonin (sCT) not containing an N-terminal disultide bridge. was investigated by circular dichroism (CD) and Fourier-transform infrared spectroscopy (FTIR) methods. Both CD and FTIR results show that the main conformational structure of [Val1, Ala7]sCT in aqueous solution is random coil structure while in trifluorethanol (TFE) it displays a strong α-helical structure. The relationship between the biological activity and the conformational structure of [Val1, Ala7]sCT is also discussed.
English
Secondary Structure in Solution of an Analog of Salmon Calcitonin:[Val1, Ala7]sCT
Abstract:
Secondary structure of [Val1, Ala7]sCT, an analog of salmon caleitonin (sCT) not containing an N-terminal disultide bridge. was investigated by circular dichroism (CD) and Fourier-transform infrared spectroscopy (FTIR) methods. Both CD and FTIR results show that the main conformational structure of [Val1, Ala7]sCT in aqueous solution is random coil structure while in trifluorethanol (TFE) it displays a strong α-helical structure. The relationship between the biological activity and the conformational structure of [Val1, Ala7]sCT is also discussed.
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Key words:
- Salmon calcitonin analog
- / CD
- / FTIR
- / peptide secondary structure
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