Novel Bis-hydroxymethylation of Imidazole and 2-Methylimidazole

Cheng He ZHOU Zhi Chang LIU Ru Gang XIE Hua Ming ZHAO

引用本文: Cheng He ZHOU,  Zhi Chang LIU,  Ru Gang XIE,  Hua Ming ZHAO. Novel Bis-hydroxymethylation of Imidazole and 2-Methylimidazole[J]. Chinese Chemical Letters, 1997, 8(1): 21-24. shu
Citation:  Cheng He ZHOU,  Zhi Chang LIU,  Ru Gang XIE,  Hua Ming ZHAO. Novel Bis-hydroxymethylation of Imidazole and 2-Methylimidazole[J]. Chinese Chemical Letters, 1997, 8(1): 21-24. shu

Novel Bis-hydroxymethylation of Imidazole and 2-Methylimidazole

  • 基金项目:

    This work is supported by the Special Funds of the State Educational Committee for Doctorate Scientific Research and the National Natural Science Foundation of P. R. China.

摘要: A novel one-pot synthesis of 4,5-bis(hydroxymethyl) imidazoles 2a-b,new ethers 3a-b and a new type of imidazolophane 4b by the bis-hydroxymethylation of imidazole or 2-methyl imidazole with formaldehyde and potassium hydroxide is reported.The structures of these compounds have been established by MS,1HNMR,IR and elemental analyses.

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  • 收稿日期:  1996-09-16
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