引用本文:
许前会, 韦萍. 芦竹碱法合成DL-色氨酸[J]. 应用化学,
2006, 23(6): 668-671.
Citation: XU Qian-Hui, WEI Ping. The Synthesis of DL-tryptophan with Gramine[J]. Chinese Journal of Applied Chemistry, 2006, 23(6): 668-671.
Citation: XU Qian-Hui, WEI Ping. The Synthesis of DL-tryptophan with Gramine[J]. Chinese Journal of Applied Chemistry, 2006, 23(6): 668-671.
芦竹碱法合成DL-色氨酸
English
The Synthesis of DL-tryptophan with Gramine
Abstract:
DL-tryptophan was synthesizd by condensing gramine with hydantoin and subsequent hydrolyzation of 5-(3-indole-methyl)hydantoin intermediate.The yield of DL-tryptophan to gramine was up to 41.6%.The optimum conditions of condensation were: 10 h reaction time,1.2:0.8:1 molar ratio of CH3I to C2H5ONa to gramine,0.9:1 molar ratio of gramine to hydantoin.The optimum conditions of hydrolysis were: 1.5 mol/L NaOH,10 h hydrolysis time,0.2 mol/L 5-(3-indolemethyl)hydantoin,and 100℃ reaction temperature.
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Key words:
- DL-tryptophan
- / gramine
- / (indolemethyl)hydantoin
- / synthesis
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