Citation: HAN Xiang-Bin, SHAO Ying, SHEN Yong-Miao. Synthesis, Crystal Structure and DNA-Binding Properties of Binuclear Copper(Ⅱ) Complex with N-Phthaloylglycinate[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(12): 2643-2648. doi: 10.3969/j.issn.1001-4861.2013.00.400 shu

Synthesis, Crystal Structure and DNA-Binding Properties of Binuclear Copper(Ⅱ) Complex with N-Phthaloylglycinate

1.
1 Department of Chemistry, Shaoxing University, Shaoxing, Zhejiang 312000, China;

Received Date: 21 May 2013
Available Online: 30 July 2013
Fund Project: 浙江省自然科学基金(No.Y508308) (No.Y508308)江苏省新型环保重点实验室(No.AE201306)资助项目。 (No.AE201306)

A new copper(Ⅱ) complex [Cu₂(DMSO)₂(ODPA)₄]·2DMSO (DMSO=dimethyl sulfoxide, ODPA=N-Phthaloylglycinate) was synthesized and characterized by single-crystal X-ray diffraction. The complex crystallizes in the triclinic system, space group P1, with cell parameters: a=10.361(2) nm, b=11.273(2) nm, c=12.126(2) nm, β=81.765(3)°, cell volume; V=1 383.6(4) nm³, number of molecules inside the cell: Z=1, D_c=1.508 g·cm^-3, the final R=0.075 0 and wR₂=0.192 7. The interaction of the complex with DNA was studied by UV spectroscopy, EtBr fluoescent probe and DNA cleavage. The results indicate that the complex could interact with DNA by partial intercalative mode. The agarose gel electrophoresis studies revealed that the complex can cleave pBR322 DNA to Form Ⅱ. CCDC: 937398.
- binuclear copper(Ⅱ) complex;crystal;PBR322DNA;CT-DNA
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沈阳化工大学材料科学与工程学院沈阳 110142