Citation: HUANG Bin, CHEN Yun-Cong, GUO Zi-Jian, HE Wei-Jiang. A New Sensitive Fluorescent H₂S Probe Based on Cu²⁺ Complex[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(11): 2283-2288. doi: 10.3969/j.issn.1001-4861.2013.00.347 shu

A New Sensitive Fluorescent H₂S Probe Based on Cu²⁺ Complex

1.
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093 China

Received Date: 16 May 2012
Available Online: 6 May 2013
Fund Project: 国家自然科学基金(No.21271100) (No.21271100)重大基础研究计划(No.2011CB935800)资助项目。 (No.2011CB935800)

As the third gasotransmitter after NOand CO, hydrogen sulfide plays essential biological roles in living systems, and developing sensitive fluorescent probe for the rapid tracking of endogenous H₂S is attracting much attention. Anew H₂S fluorescent probe was constructed in this study based on a copper complex formed by a new NBD fluorescent ligand, in which a Cu²⁺ chelator was incorporated. This probe displays very weak emission owing to the emission quenching effect of Cu²⁺, and it is able to sense H₂S by exhibiting distinct emission enhancement upon H₂S addition. The S₂-induced Cu²⁺ removal from this complex was proposed as the sensing mechanism of this Cu²⁺ complex-based probe. Besides the quick response, the high sensing selectivity over other anion of this probe has also been confirmed, and its detection limit was estimated to be ~0.2 μmol·L^-1, and the linear range is 1~20 μmol·L^-1.
- hydrogen sulfide;fluorescence;molecular probe;sensitivity
1. [1]
  [1] Szabo C. Nat. Rev. Drug Discovery 2007,6:917-935
2. [2]
  [2] Lowicka E, Beltowski J. Pharmacol. Rep., 2007,59:4-24
3. [3]
  [3] Li L, Rose P, Moore P K. Annu. Rev. Pharmacol. Toxicol.,2011,51:169-187
4. [4]
  [4] DU Jun-Bao (杜军保), CHEN Xiao-Bo(陈小波), GENG Bin(耿彬),et al. J.PekingUniv.:HealthSci.(Beijing DaxueXuebao: Yixue Ban), 2002,34(2):187-187
5. [5]
  [5] QIU Wen-Bing(邱文冰), JIN Hong(金红), WANG Dong-Ming(王东明). Adv. Cardiovasc. Dis. (Xinxueguan BingxueJinzhan), 2006,27(suppl 1):84-87
6. [6]
  [6] Yang G D, Wu L Y, Jiang B, et al. Science, 2008,322:587-590
7. [7]
  [7] Yang C, Yang Z, Zhang M, et al. PLoS ONE, 2011,6:e21971
8. [8]
  [8] Li L, Bhatia M, Zhu Y Z, et al. FASEB J., 2005,19:1196-1198
9. [9]
  [9] Blackstone E, Morrison M, Roth M B. Science, 2005,308:518-518
10. [10]
  [10]Eto K, Asada T A, Arima K, et al. Biochem. Biophys. Res.Commun., 2002,293:1485-1488
11. [11]
  [11]Kamoun P, Belardinelli M-C, Chabli A, et al. Am. J. Med.Genet. Part A, 2003,116:310-311
12. [12]
  [12]Yang W, Yang G, Jia X, et al. J. Physiol., 2005,569:519-531
13. [13]
  [13]Fiorucci S, Antonelli E, Mencarelli A, et al.Hepatology,2005,42:539-548
14. [14]
  [14]Lei W, Dasgupta P K. Anal. Chim. Acta, 1989,226:165-170
15. [15]
  [15]Jimnez D, Matinez-manez R, Sancenon F, et al. J. Am.Chem. Soc., 2003,125:9000-9001
16. [16]
  [16]Richardson C J, Magee E A M, Cummings J H. Clin. Chim.Acta, 2000,293:115-125
17. [17]
  [17]Searcy D G, Peterson M A. Anal. Biochem., 2004,324:269-275
18. [18]
  [18]Radford-Knoery J, Cutter G A. Anal. Chem., 1993,65:976-982
19. [19]
  [19]Berube P R, Parkinson P D, Hall E R. J. Chromatogr. A,1999,830:485-489
20. [20]
  [20]Kabil O, Banerjee R. J. Biol. Chem., 2010,285:21903-21907
21. [21]
  [21]Olson K R. Biochim. Biophys. Acta Bioenerg., 2009,1787:856-863
22. [22]
  [22]Furne J, Saeed A, Levitt M D. Am. J. Physiol. Regul. Integr.Comp. Physiol., 2008,295:R1479-R1485
23. [23]
  [23]Lippert A R, New E J, Chang C J. J. Am. Chem. Soc., 2011,133:10078-10080
24. [24]
  [24]Peng H, Cheng Y, Dai C, et al. Angew. Chem. Int. Ed.,2011,50:9672-9765
25. [25]
  [25]Liu C, Pan J, Li S, Zhao Y, et al. Angew. Chem. Int. Ed.,2011,50:10327-10329
26. [26]
  [26]Qian Y, Karpus J, Kabil O, et al. Nat. Commun., 2011,2:495
27. [27]
  [27]Chen Y, Zhu C, Yang Z, et al. Angew. Chem. Int. Ed.,2013,52:1688-1691
28. [28]
  [28]Sasakura K, Hanaoka K, Shibuya N, et al. J. Am. Chem.Soc., 2011,133:18003-18005
29. [29]
  [29]Hou F, Huang L, Xi P, et al. Inorg. Chem., 2012,51:2454-2460
30. [30]
  [30]Hou F, Huang L, Xi P, et al. Dalton Trans., 2012,41:5799-5804
31. [31]
  [31]Xuan W, Sheng C, Cao Y, et al. Angew. Chem. Int. Ed.2012,51:2282-2284
32. [32]
  [32]Lin V S, Chang C J. Curr. Opin. Chem. Biol., 2012,16:595-601
33. [33]
  [33]Qian F, Zhang C, Zhang Y, et al. J. Am. Chem. Soc., 2009,131:1460-1468
34. [34]
  [34]Uchiyama S, Santa T, Fukushima T, et al. J. Chem. Soc.,Perkin Trans. 2., 1998:2165-2174
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通讯作者: 陈斌, bchen63@163.com

A New Sensitive Fluorescent H₂S Probe Based on Cu²⁺ Complex