Citation: Mostafa M H Khalil, Eglal R Souaya, Eman H Ismail, Eman Rabie. Ternary Transition Metal Complexes of Nitrilotriacetic Acid and Valine or Leucine：Synthesis and Biological Applications[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(9): 1969-1978. doi: 10.3969/j.issn.1001-4861.2013.00.319 shu

Ternary Transition Metal Complexes of Nitrilotriacetic Acid and Valine or Leucine：Synthesis and Biological Applications

1.
1 Chemistry Department, Faculty of Science, Ain Shams University, 11566, Abbassia, Cairo, Egypt.;

Received Date: 16 February 2013
Available Online: 28 May 2013

Ternary complexes of Ni(Ⅱ), Cu(Ⅱ), and Zn(Ⅱ) with nitrilotriacetic acid HNTA^2- as a primary ligand and valine or leucine as a secondary ligand were synthesized in slightly acidic medium. The new complexes were characterized by elemental analysis, FTIR, UV-Vis spectroscopy, thermal analysis, magnetic measurements and mass spectroscopy. The results indicate that the ternary complexes are isolated in M:HNTA:valine(or leucine) ratio of 1:1:1, and the molecular structures are suggested to be[M(HNTA)(valine)(H₂O)₂]·1.5H₂O and[M(HNTA) (leucine)(H₂O)₂]·1.5H₂O, where M=Ni(Ⅱ) or Cu(Ⅱ) and H₂[Zn(NTA)(valine)(H₂O)] H₂O. The suggested geometry of our ternary metal complexes is an octahedral symmetry. The antimicrobial activities of prepared complexes against Escherichia coli, Staphylococcus aureus, Candida albicans and Aspergillus flavus (isolates from Microanalytical Center, Faculty of Science, Cairo University) were also investigated. The complexes were tested in vitro to assess growth inhibitory activity against the bacterial and fungal species with standard antibacterial and antifungal agents according to the recommended known method.
- valine;leucine;ternary complexes;biological applications
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