Citation: ZHU Li-Na, WANG Hai-Xian, SUN Run-Feng, LI Ping, KONG De-Ming, LI Xiao-Zeng. Disruption of G-Quadruplex DNA by Ag⁺ and Hg²⁺ and Its Application to DNA Logic Gate[J]. Chinese Journal of Inorganic Chemistry, ;2013, 29(10): 2215-2224. doi: 10.3969/j.issn.1001-4861.2013.00.259 shu

Disruption of G-Quadruplex DNA by Ag⁺ and Hg²⁺ and Its Application to DNA Logic Gate

1.
1 Department of Chemistry, Tianjin University, Tianjin 300072, China;

Received Date: 1 March 2013
Available Online: 19 April 2013
Fund Project: 国家自然科学基金(No.20801040,21175072)资助项目 (No.20801040,21175072)

The G-quadruplex-disrupting abilities of Ag⁺ and Hg²⁺ ions were investigated by utilizing the metal ions-mediated circular dichroism (CD) spectrum changes of four representative G-quadruplexes. The results show that Ag⁺ ion can disrupt G-quadruplexes by chelating to Gbases and thus can be used as a general G-quadruplex-disrupting agent. The results also suggest that Hg²⁺ ion may disrupt G-quadruplexes by formation of T-Hg²⁺-Tbase pairs as well as other species. The G-quadruplexes disrupted by Ag⁺ and Hg²⁺ can be recovered by cysteine (Cys), a thiol-containing amino acid, due to the tight binding interactions between Cys and the metal ions. Thus, the system by using Ag⁺ (or Hg²⁺) and Cys as two inputs and CDsignal as output can behave as a DNA IMPLICATIONlogic gate.
- G-quadruplex; DNA logic gate; Ag⁺; Hg²⁺; cysteine; circular dichroism
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Disruption of G-Quadruplex DNA by Ag+ and Hg2+ and Its Application to DNA Logic Gate

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通讯作者: 陈斌, bchen63@163.com

Disruption of G-Quadruplex DNA by Ag⁺ and Hg²⁺ and Its Application to DNA Logic Gate