Citation: XIE Yun-Fu, TANG Liang-Fu. Synthesis, Structure and Antitumor Activity of Organotin 1, 1'-Methylenebis(1H-pyrazole-4-carboxylates)[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(4): 755-761. doi: 10.11862/CJIC.2020.089 shu

Synthesis, Structure and Antitumor Activity of Organotin 1, 1'-Methylenebis(1H-pyrazole-4-carboxylates)

XIE Yun-Fu ¹ ,
TANG Liang-Fu ^2,,

1.
College of Science, Tianjin University of Science and Technology, Tianjin 300457, China
2.
State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

Corresponding author: TANG Liang-Fu, lftang@nankai.edu.cn
Received Date: 3 September 2019
Revised Date: 23 December 2019

Figures(4)

Four triorganotin 1, 1'-methylenebis(1H-pyrazole-4-carboxylates) (CH₂(PzCO₂SnR₃)₂, R=Ph (1), cyclohexyl (2), Et (3), n-Bu (4)) have been synthesized via the reaction of R₃SnOH or (R₃Sn)₂O with 1, 1'-methylenebis(1H-pyrazole-4-carboxylic acid). All these complexes were characterized by elemental analysis, IR and multinuclear NMR (¹H, ¹³C and ¹¹⁹Sn). The structures of 1 and 3 have been confirmed by the X-ray single crystal diffraction analysis, suggesting that the pyrazoyl nitrogen atoms don't participate in coordination to the tin atoms, and the carboxylate groups show considerably different coordination modes in these two complexes. In addition, complex 1 only shows a dinuclear structure, while complex 3 forms a 2D-coordination polymer with 32-membered macrocyclic units through the bridging carboxylate oxygen atoms. The cytotoxic activity of these complexes for MCF-7 and A549 cells was tested, showing that they displayed good cytotoxicities for these two cells in vitro.CCDC: 1949278, 1; 1949279, 3.
- N ligand,
- organotin carboxylate,
- X-ray crystal structure,
- antitumor activity
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