Citation: ZHANG Si-Qi, GAO Li-Hua, ZHAO Hua, WANG Ke-Zhi. pH-Sensitive Iridium, Ruthenium and Platinum Complexes for Tumor-Specific Fluorescence Imaging and Cancer Therapy[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(11): 1974-1986. doi: 10.11862/CJIC.2019.231 shu

pH-Sensitive Iridium, Ruthenium and Platinum Complexes for Tumor-Specific Fluorescence Imaging and Cancer Therapy

1.
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China
2.
School of Science, Beijing Technology and Business University, Beijing 100048, China

Corresponding author: WANG Ke-Zhi, kzwang@bnu.edu.cn
Received Date: 3 September 2019
Revised Date: 24 September 2019

Figures(8)

Acidic pH in tumor tissues provides a powerful platform for accurate tumor diagnosis and efficient therapy. The pH-sensitive iridium, ruthenium and platinum metal complexes have attracted increasing attention due to their high physicochemical stability, favorable spectral properties and tumor targetability. In this review, we summarize formation mechanisms of the acidic tumor microenvironment and recent advances on the acidic microenvironment-sensitive metal complexes of iridium, ruthenium and platinum for tumor imaging chemotherapy agents.
- metal complex,
- pH sensitive,
- tumor imaging,
- tumor therapy
1. [1]
  Qiu K Q, Wang J Q, Song C L, et al. ACS Appl. Mater. Interfaces, 2017, 9(22):18482-18492 doi: 10.1021/acsami.7b02977
2. [2]
  Ganipineni L P, Danhier F, Préat V. J. Controlled Release, 2018, 281:42-57 doi: 10.1016/j.jconrel.2018.05.008
3. [3]
  Wang C S, Wang Z H, Zhao T, et al. Biomaterials, 2018, 157:62-75 doi: 10.1016/j.biomaterials.2017.12.002
4. [4]
  Tringale K R, Pang J, Nguyen Q T. WIREs Syst. Biol. Med., 2018, 10(8924):e1412
5. [5]
  Zhou Q, Zhang L, Yang T H, et al. Int. J. Nanomed., 2018, 13:2921-2942 doi: 10.2147/IJN.S158696
6. [6]
  Wang M N, Zhao J Z, Zhang L S, et al. J. Cancer, 2017, 8(5):761-773 doi: 10.7150/jca.17648
7. [7]
  Romero-Garcia S, Moreno-Altamirano M M B, Prado-Garcia H, et al. Front. Immunol., 2016, 7:52
8. [8]
  Li L, Kang L, Zhao W, et al. Cancer Lett., 2017, 400:89-98 doi: 10.1016/j.canlet.2017.04.034
9. [9]
  Hofmann M, Pflanzer R, Habib A, et al. Transl. Oncol, 2016, 9(3):179-183
10. [10]
  Wen Y A, Xing X P, Harris J W, et al. Cell Death Dis., 2017, 8(2):e2593
11. [11]
  Amith S R, Fliegel L. Semin. Cancer Biol., 2017, 43:35-41 doi: 10.1016/j.semcancer.2017.01.004
12. [12]
  Hinton A, Bond S, Forgac M. Pfluegers Arch. Eur. J. Phy., 2009, 457(3):589-598 doi: 10.1007/s00424-007-0382-4
13. [13]
  Liu Z P, Zhang C L, He W J, et al. New J. Chem., 2010, 34(4):656-660 doi: 10.1039/b9nj00703b
14. [14]
  Chen Y C, Zhu C C, Cen J J, et al. Chem. Sci., 2015, 6(5):3187-3194 doi: 10.1039/C4SC04021J
15. [15]
  Chen X H, Chen Z W, Hu B H, et al. Small, 2018, 14(9):1703164 doi: 10.1002/smll.201703164
16. [16]
  Shen S L, Zhang X F, Ge Y Q, et al. Sens. Actuators B, 2018, 256:261-267 doi: 10.1016/j.snb.2017.10.103
17. [17]
  Hong K I, Park S H, Lee S M, et al. Sens. Actuators B, 2019, 286:148-153 doi: 10.1016/j.snb.2019.01.101
18. [18]
  Zhao X J, Chen Y, Niu G Y, et al. ACS Appl. Mater. Interfaces, 2019, 11(14):13134-13139 doi: 10.1021/acsami.9b02228
19. [19]
  Yuan P, Ruan Z, Li T W, et al. Nanomed-Nano. Technol., 2019, 15(1):198-207
20. [20]
  Dickerson M, Sun Y, Howerton B, et al. Inorg. Chem., 2014, 53(19):10370-10377 doi: 10.1021/ic5013796
21. [21]
  Zheng Y, He L, Zhang D Y, et al. Dalton Trans., 2017, 46(34):11395-11407 doi: 10.1039/C7DT02273E
22. [22]
  Martinez M A, Carranza M P, Massaguer A, et al. Inorg. Chem., 2017, 56(22):13679-13696 doi: 10.1021/acs.inorgchem.7b01178
23. [23]
  Rosca C Y, Horlescu P, Stan C S, et al. Turk. J. Chem., 2017, 41(5):648-657
24. [24]
  Li F Y, Du Y, Liu J A, et al. Adv. Mater., 2018, 30(35):1802808 doi: 10.1002/adma.201802808
25. [25]
  Yang G B, Xu L G, Xu J, et al. Nano Lett., 2018, 18(4):2475-2484 doi: 10.1021/acs.nanolett.8b00040
26. [26]
  Xia F F, Hou W X, Zhang C L, et al. Acta Biomater., 2018, 68:308-319 doi: 10.1016/j.actbio.2017.12.034
27. [27]
  Danaei M, Dehghankhold M, Ataei S, et al. Pharmaceutics, 2018, 10(2):57 doi: 10.3390/pharmaceutics10020057
28. [28]
  Urandur S, Banala V T, Shukla R P, et al. ACS Appl. Mater. Interfaces, 2018, 10(15):12960-12974 doi: 10.1021/acsami.7b19109
29. [29]
  Cai Y, Wei Z, Song C H, et al. Chem. Soc. Rev., 2019, 48(1):22-37 doi: 10.1039/C8CS00494C
30. [30]
  Wang Y G, Zhou K J, Huang G, et al. Nat. Mater., 2014, 13(2):204-212 doi: 10.1038/nmat3819
31. [31]
  Kando A, Hisamatsu Y, Ohwada H, et al. Inorg. Chem., 2015, 54(11):5342-5357 doi: 10.1021/acs.inorgchem.5b00369
32. [32]
  Zhang S J, Hosaka M, Yoshihara T, et al. Cancer Res., 2010, 70(11):4490-4498 doi: 10.1158/0008-5472.CAN-09-3948
33. [33]
  Zhang P Y, Huang H Y, Chen Y, et al. Biomaterials, 2015, 53:522-531 doi: 10.1016/j.biomaterials.2015.02.126
34. [34]
  Fernández-Moreira V, Thorp-Greenwood F L, Coogan M P. Chem. Commun., 2010, 46(2):186-202 doi: 10.1039/B917757D
35. [35]
  Qiu K Q, Chen Y, Rees T W, et al. Coord. Chem. Rev., 2019, 378:66-86 doi: 10.1016/j.ccr.2017.10.022
36. [36]
  Zhou Z X, Liu J P, Rees T W, et al. Proc. Natl. Acad. Sci. U.S.A., 2018, 115(22):5664-5669 doi: 10.1073/pnas.1802012115
37. [37]
  Zhao X Z, Li M L, Wen S, et al. Chem. Commun., 2018, 54(51):7038-7041 doi: 10.1039/C8CC03786H
38. [38]
  Liu Y, Hammitt R, Lutterman D A, et al. Inorg. Chem., 2008, 48(1):375-385
39. [39]
  Poynton F E, Bright S A, Blasco S, et al. Chem. Soc. Rev., 2017, 46(24):7706-7756 doi: 10.1039/C7CS00680B
40. [40]
  Meng T T, Xue L X, Wang H, et al. J. Mater. Chem. C, 2017, 5(13):3390-3396 doi: 10.1039/C7TC00494J
41. [41]
  Li L L, Xing H, Zhang J J, et al. Acc. Chem. Res., 2019, 52(9):2415-2426 doi: 10.1021/acs.accounts.9b00167
42. [42]
  Kahn J S, Hu Y W, Willner I. Acc. Chem. Res., 2017, 50(4):680-690 doi: 10.1021/acs.accounts.6b00542
43. [43]
  Wang L, Li C. J. Mater. Chem. C, 2011, 21(40):15862-15871 doi: 10.1039/c1jm12072g
44. [44]
  Feng L Z, Dong Z L, Tao D L, et al. Natl. Sci. Rev., 2017, 5(2):269-286
45. [45]
  Zheng H Q, Xing L, Cao Y Y, et al. Coord. Chem. Rev., 2013, 257(11/12):1933-1944
46. [46]
  Warburg O, Wind F, Negelein E. J. Gen. Physiol., 1927, 8(6):519-530 doi: 10.1085/jgp.8.6.519
47. [47]
  Tennant D A, Durán R V, Gottlieb E. Nat. Rev. Cancer, 2010, 10(4):267-277 doi: 10.1038/nrc2817
48. [48]
  Gatenby R A, Gillies R J. Nat. Rev. Cancer, 2004, 4(11):891-899 doi: 10.1038/nrc1478
49. [49]
  De Preter G, Neveu M A, Danhier P, et al. Oncotarget, 2016, 7(3):2910-2920
50. [50]
  Kato Y, Ozawa S, Miyamoto C, et al. Cancer Cell Int., 2013, 13(1):89 doi: 10.1186/1475-2867-13-89
51. [51]
  Böhme I, Bosserhoff A K. Pigment Cell Melanoma Res., 2016, 29(5):508-523 doi: 10.1111/pcmr.12495
52. [52]
  Gabriel H, Axel S, Marc D, et al. Clin. Cancer Res., 2002, 8(4):1284-1291
53. [53]
  Gallagher F A, Helen S, Kettunen M I, et al. Cancer Res., 2015, 75(19):4109-4118 doi: 10.1158/0008-5472.CAN-15-0857
54. [54]
  Stubbs M, Mcsheehy P M J, Griffiths J R, et al. Mol. Med., 2000, 6(1):15-19
55. [55]
  Parks S K, Johanna C, Jacques P. Nat. Rev. Cancer, 2013, 13(9):611-623 doi: 10.1038/nrc3579
56. [56]
  Schwartz L, Supuran C T, Alfarouk K O. Anti-Cancer Agents Med. Chem., 2017, 17(2):164-170 doi: 10.2174/1871520616666161031143301
57. [57]
  Cardone R A, Valeria C, Reshkin S J. Nat. Rev. Cancer, 2005, 5(10):786-795 doi: 10.1038/nrc1713
58. [58]
  Damaghi M, Wojtkowiak J, Gillies R. Front. Physiol., 2013, 4(370):1-10
59. [59]
  Hée V F V, Labar D, Dehon G, et al. Oncotarget, 2017, 8(15):24415-24428
60. [60]
  Pérez-Escuredo J, Hée V F V, Sboarina M, et al. Biochim. Biophys. Acta, 2016, 1863(10):2481-2497 doi: 10.1016/j.bbamcr.2016.03.013
61. [61]
  Pérez-Sayáns M, García-García A, Reboiras-López M D, et al. Int. J. Oncol., 2009, 34(6):1513-1520
62. [62]
  Sennoune S R, Luo D, Martinez-Zaguilán R. Cell Biochem. Biophys., 2004, 40(2):185-206 doi: 10.1385/CBB:40:2:185
63. [63]
  Spugnini E P, Citro G, Fais S. J. Exp. Clin. Cancer Res., 2010, 29(1):44 doi: 10.1186/1756-9966-29-44
64. [64]
  Kulshrestha A, Katara G K, Ibrahim S, et al. Oncotarget, 2015, 6(6):3797-3810
65. [65]
  Stefano F, Angelo D M, Haiyan Y, et al. Cancer Res., 2007, 67(22):10627-10630 doi: 10.1158/0008-5472.CAN-07-1805
66. [66]
  Sennoune S R, Karina B, Martínez G M, et al. Am. J. Physiol. Cell Physiol., 2004, 286(6):1443-52 doi: 10.1152/ajpcell.00407.2003
67. [67]
  Sepehrpour H, Fu W X, Sun Y, et al. J. Am. Chem. Soc., 2019, 141(36):14005-14020 doi: 10.1021/jacs.9b06222
68. [68]
  Ng W M, Guo X Y, Cheung W M, et al. Dalton Trans., 2019, 48:13315-13325 doi: 10.1039/C9DT02457C
69. [69]
  Rojas Perez Y, Slep L D, Etchenique R. Inorg. Chem., 2019, 58(17):11606-11613 doi: 10.1021/acs.inorgchem.9b01485
70. [70]
  Gao F, Chen X, Zhou F, et al. Inorg. Chim. Acta, 2009, 362(14):4960-4966 doi: 10.1016/j.ica.2009.07.034
71. [71]
  Gao F, Chao H, Zhou F, et al. Inorg. Chem. Commun., 2007, 10(2):170-173 doi: 10.1016/j.inoche.2006.10.009
72. [72]
  Gao F, Chen X, Sun Q, et al. Inorg. Chem. Commun., 2012, 16(2):25-27
73. [73]
  San S T, Yanagisawa S, Inagaki K, et al. Phys. Chem. Chem. Phys., 2017, 19(4):25734-25745
74. [74]
  Karawajczyk A, Buda F. J. Biol. Inorg. Chem., 2005, 10(2):208-208 doi: 10.1007/s00775-005-0628-6
75. [75]
  Shin A, Yasuki M, Shiori O, et al. Inorg. Chem., 2011, 50(3):806-18 doi: 10.1021/ic101164g
76. [76]
  Shinsuke M, Yosuke H, Toshihiro S, et al. Inorg. Chem., 2016, 51(23):12697-12706
77. [77]
  Xia Y M, Wang Y M, Wang Y P, et al. Colloids Surf. B, 2011, 88(2):674-681 doi: 10.1016/j.colsurfb.2011.07.059
78. [78]
  Akihiro N, Yosuke H, Shinsuke M, et al. Inorg. Chem., 2014, 53(1):409-422 doi: 10.1021/ic402387b
79. [79]
  Kando A, Hisamatsu Y, Ohwada H, et al. Inorg. Chem., 2015, 54(11):5342-5357 doi: 10.1021/acs.inorgchem.5b00369
80. [80]
  Dolan C, Moriarty R D, Lestini E, et al. J. Inorg. Biochem., 2013, 119(2):65-74
81. [81]
  Liu J B, Vellaisamy K, Li G D, et al. J. Mater. Chem. B, 2018, 6(23):3855-3858 doi: 10.1039/C8TB00666K
82. [82]
  Yu H J, Hao Z F, Peng H L, et al. Sens. Actuators B, 2017, 252:313-321 doi: 10.1016/j.snb.2017.05.164
83. [83]
  Adam A M A. J. Mol. Struct., 2019, 1195:43-57 doi: 10.1016/j.molstruc.2019.05.097
84. [84]
  Aljuhani E. Russ. J. Gen. Chem., 2019, 89(5):1042-1050 doi: 10.1134/S1070363219050268
85. [85]
  Chen Y, Qiao L P, Ji L N, et al. Biomaterials, 2014, 35(1):2-13 doi: 10.1016/j.biomaterials.2013.09.051
86. [86]
  Deng Z Q, Yu L L, Gao W Q, et al. Chem. Commun., 2015, 51(13):2637-2640 doi: 10.1039/C4CC07926D
87. [87]
  Zhao Z N, Gao P, You Y Y, et al. Chem. Eur. J., 2018, 24(13):3289-3298 doi: 10.1002/chem.201705561
88. [88]
  Presa A, Vázquez G, Barrios L A, et al. Inorg. Chem., 2018, 57(7):4009-4022 doi: 10.1021/acs.inorgchem.8b00146
89. [89]
  Yulia Yu S D, Legin A A, Jakupec M A, et al. Inorg. Chem., 2011, 50(21):10673-81 doi: 10.1021/ic2010612
90. [90]
  Howerton B S, Heidary D K, Glazer E C. J. Am. Chem. Soc., 2012, 134(20):8324 doi: 10.1021/ja3009677
91. [91]
  Hufziger K T, Thowfeik F S, Charboneau D J, et al. J. Inorg. Biochem., 2014, 130(1):103-111
92. [92]
  Jin S X, Guo Y, Song D F, et al. Inorg. Chem., 2019, 58(9):6507-6516 doi: 10.1021/acs.inorgchem.9b00708
93. [93]
  Guo Y, Zhang S R, Yuan H, et al. Dalton Trans., 2019, 48(11):3571-3575 doi: 10.1039/C9DT00335E
94. [94]
  Ma J, Yang X D, Hao W P, et al. Eur. J. Med. Chem., 2017, 128:45-55 doi: 10.1016/j.ejmech.2017.01.032
95. [95]
  Wang H, Qiu Z H, Liu H, et al. Front. Chem., 2019, 7:39 doi: 10.3389/fchem.2019.00039
96. [96]
  Tsai J L L, Zou T T, Liu J, et al. Chem. Sci., 2015, 6(7):3823-3830 doi: 10.1039/C4SC03635B
97. [97]
  Chung C Y S, Li S P Y, Lo K K W, et al. Inorg. Chem., 2016, 55(9):4650-4663 doi: 10.1021/acs.inorgchem.6b00513
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