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Citation: PAN Jia-Bao, CHEN Xi, FANG Wen-Juan, LIU Wei, YU Guang-Wei. Water Soluble Cu(Ⅱ) and Ni(Ⅱ) Phthalocyanine: Syntheses and in Vitro Synergistic Anticancer Activities of Photodynamic Therapy and Chemotherapy Effects[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(5): 889-896. doi: 10.11862/CJIC.2018.127 shu

Water Soluble Cu(Ⅱ) and Ni(Ⅱ) Phthalocyanine: Syntheses and in Vitro Synergistic Anticancer Activities of Photodynamic Therapy and Chemotherapy Effects

State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China

Corresponding author: LIU Wei, weiliu@sdu.edu.cn
Received Date: 31 October 2017
Revised Date: 30 March 2018

Figures(9)

Water-soluble Cu(Ⅱ) phthalocyanine 6 and Ni(Ⅱ) phthalocyanine 7 were successfully synthesized starting from 1, 2-dicynobenzen derivative. The photophysical and photochemical properties of these phthalocyanines show that they are not only very stable towards either heat or light, but also could yield singlet oxygen moderately. In vitro cell study demonstrates that both 6 and 7 could inhibit the growth of cancer cells in dark and also exhibit photodynamic therapy effect upon exposure to red light. These results show that these compounds have synergistic anticancer activities of photodynamic therapy and chemotherapy effects.
- Cu (Ⅱ) phthalocyanine,
- Ni (Ⅱ) phthalocyanine,
- singlet oxygen,
- phototoxicity
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