Citation: LI Lu-Xi, SUN Ying, XIE Qing, SUN Yu-Bing, LI Kun-Hua, LI Wei, YOU Zhong-Lu. A Maltolato-Coordinated Oxovanadium (Ⅴ) Complex Derived from N′-(3-Bromo-5-chloro-2-hydroxybenzylidene)-3-hydroxyl-4-methoxybenzohydrazide: Synthesis, Crystal Structure, and Insulin-Enhancing Activity[J]. Chinese Journal of Inorganic Chemistry, ;2016, 32(2): 369-376. doi: 10.11862/CJIC.2016.040 shu

A Maltolato-Coordinated Oxovanadium (Ⅴ) Complex Derived from N′-(3-Bromo-5-chloro-2-hydroxybenzylidene)-3-hydroxyl-4-methoxybenzohydrazide: Synthesis, Crystal Structure, and Insulin-Enhancing Activity

LI Lu-Xi ¹ ,
SUN Ying ¹ ,
XIE Qing ² ,
SUN Yu-Bing ² ,
LI Kun-Hua ² ,
LI Wei ² ,
YOU Zhong-Lu ^1,*,,

1.
Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China
2.
Department of Radiology, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116023, China

Corresponding author: YOU Zhong-Lu, youzhonglu@126.com
Received Date: 18 November 2015
Revised Date: 21 December 2015

Figures(6)

An aroylhydrazone compound, N′-(3-bromo-5-chloro-2-hydroxybenzylidene)-3-hydroxyl-4-methoxyben-zohydrazide (H₂L), was prepared and characterized by elemental analysis, IR, UV, HRMS, ¹H NMR and ¹³C NMR spectrum. Reaction of H₂L, maltol (3-hydroxy-2-methyl-4-pyrone) and VO (acac)₂ in methanol afforded a maltolato-coordinated oxovanadium (Ⅴ) complex, [VO (mat) L]·MeOH. The complex was characterized by elemental analysis, IR and UV spectra. Thermal analysis was also performed. Structures of H₂L and the complex were further confirmed by single crystal X-ray diffraction. Insulin-mimetic tests on C2C12 muscle cells indicate that the complex significantly stimulated cell glucose utilization with cytotoxicity at 0.07 g·L^-1. CCDC: 1437202, H₂L; 1437201, the complex.
- oxovanadium complex,
- maltol,
- aroylhydrazone,
- crystal structure,
- insulin-enhancing activity
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