Citation: GAO Chuan-Zhu, CHEN Ji, WANG Tian-Shuai, ZHANG Yan, QIAN Yun-Xu, YANG Bo, GOU Shao-Hua, DONG Peng, ZHANG Ying-Jie. Synthesis and Antitumor Activity of Dinuclear Platinum Complexes with (1iR, 1iiR, 2iR, 2iiR)-Ni, Nii-(1, 3-Phenylenebis(methylene))dicyclohexane-1, 2-diamie as the Ligan[J]. Chinese Journal of Inorganic Chemistry, ;2015, (11): 2188-2196. doi: 10.11862/CJIC.2015.277
-
Seven diculear platinum complexes with the new chiral ligand, (1iR,1iiR,2iR,2iiR)-Ni, Nii-(1,3-phenylenebis(methylene))dicyclohexane-1,2-diamine (HL), were designed, synthesized and spectrally characterized by IR, 1H NMR, 13C NMR, ESI-MS and microanalyses. The cytotoxicities of targeted dinuclear platinum compounds against human HepG-2, A549, HCT-116 and MCF-7 cell lines were evaluated by MTT assay. Results indicated that all compounds exhibited positive activity to HepG-2, A549 and HCT-116 cell lines, but none of them showed activity to MCF-7 cell line. Among them, compound P7, owing to 3-hydroxycyclobutane-1,1-dicarboxylate as the leaving group, gave better antitumor activity than carboplatin against HepG-2 and A549 cell lines, and close cytotoxicity to oxaliplatin against HCT-116 cell line.
-
-
[1]
[1] Zhang J C, Wang L W, Xing Z Y, et al. Anti-Cancer Agents Med. Chem., 2010,10(4),272-282
-
[2]
[2] Connors T A, Cleare M J, Harrap K R. Cancer Treat. Rev., 1979,63(9/10):1499-1502
-
[3]
[3] Ho Y P, Au-Yeung S C F, To K K W. Med. Res. Rev., 2003,23(5):633-655
-
[4]
[4] Ruhayel R A, Langner J S, Oke M J, et al. J. Am. Chem. Soc., 2012,134(16):7135-7146
-
[5]
[5] Wang A H, Nathans J, Marel G, et al. Nature, 1978,276 (5687): 471-474
-
[6]
[6] Liu H K, Sadler P J. Acc. Chem. Res., 2011,44(5):349-359
-
[7]
[7] de Gramont A, Figer A, Seymour M, et al. J. Clin. Oncol., 2000,18(16):2938-2947
-
[8]
[8] Gao C Z, Fei F, Wang T S, et al. J. Coord. Chem., 2013,66 (6):1068-1076
-
[9]
[9] Liu F F, Zhou Z P, Gou S H, et al. J. Coord. Chem., 2014, 67(17):2858-2866
-
[10]
[10] Gao C Z, Wang T S, Chen J, et al. J. Coord. Chem., 2014, 67(13):2195-2203
-
[11]
[11] Lee D W, Ha H J, Lee W K. Synth. Commun., 2007,37(5): 737-742
-
[12]
[12] Alley M C, Scudiero D A, Monks A, et al. Cancer Res., 1988,48(3):589-601
-
[13]
[13] Zhang J C, Zhang F F, Wang L W, et al. J. Coord. Chem., 2012,65(12):2159-2169
-
[14]
[14] ZHANG Jin-Chao(张金超), LI Lu-Wei(李路伟), WANG Li- Wei(王立伟), et al. Chinese J. Inorg. Chem. (无机化学学 报), 2010,26(9):1699-1702
-
[15]
[15] Li L W, Zhang J C, Ma L L, et al. J. Coord. Chem., 2013,66 (4):638-649
-
[16]
[16] ZHANG Jin-Chao(张金超), WANG Li-Wei(王立伟), LI Lu-Wei(李路伟), et al. Chinese J. Inorg. Chem. (无机化学学 报), 2011,27(3):565-570
-
[17]
[17] Enos G, Mambanda A, Jaganyi D. J. Coord. Chem., 2013,66 (24):4280-4291
-
[1]
-
-
[1]
Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
-
[2]
Qilu DU , Li ZHAO , Peng NIE , Bo XU . Synthesis and characterization of osmium-germyl complexes stabilized by triphenyl ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1088-1094. doi: 10.11862/CJIC.20240006
-
[3]
Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two LnⅢ3 complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
-
[4]
Endong YANG , Haoze TIAN , Ke ZHANG , Yongbing LOU . Efficient oxygen evolution reaction of CuCo2O4/NiFe-layered bimetallic hydroxide core-shell nanoflower sphere arrays. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 930-940. doi: 10.11862/CJIC.20230369
-
[5]
Jingjing QING , Fan HE , Zhihui LIU , Shuaipeng HOU , Ya LIU , Yifan JIANG , Mengting TAN , Lifang HE , Fuxing ZHANG , Xiaoming ZHU . Synthesis, structure, and anticancer activity of two complexes of dimethylglyoxime organotin. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1301-1308. doi: 10.11862/CJIC.20240003
-
[6]
Qiangqiang SUN , Pengcheng ZHAO , Ruoyu WU , Baoyue CAO . Multistage microporous bifunctional catalyst constructed by P-doped nickel-based sulfide ultra-thin nanosheets for energy-efficient hydrogen production from water electrolysis. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1151-1161. doi: 10.11862/CJIC.20230454
-
[7]
Xin MA , Ya SUN , Na SUN , Qian KANG , Jiajia ZHANG , Ruitao ZHU , Xiaoli GAO . A Tb2 complex based on polydentate Schiff base: Crystal structure, fluorescence properties, and biological activity. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1347-1356. doi: 10.11862/CJIC.20230357
-
[8]
Zhaoyang WANG , Chun YANG , Yaoyao Song , Na HAN , Xiaomeng LIU , Qinglun WANG . Lanthanide(Ⅲ) complexes derived from 4′-(2-pyridyl)-2, 2′∶6′, 2″-terpyridine: Crystal structures, fluorescent and magnetic properties. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1442-1451. doi: 10.11862/CJIC.20240114
-
[9]
Xinting XIONG , Zhiqiang XIONG , Panlei XIAO , Xuliang NIE , Xiuying SONG , Xiuguang YI . Synthesis, crystal structures, Hirshfeld surface analysis, and antifungal activity of two complexes Na(Ⅰ)/Cd(Ⅱ) assembled by 5-bromo-2-hydroxybenzoic acid ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1661-1670. doi: 10.11862/CJIC.20240145
-
[10]
Yuanpei ZHANG , Jiahong WANG , Jinming HUANG , Zhi HU . Preparation of magnetic mesoporous carbon loaded nano zero-valent iron for removal of Cr(Ⅲ) organic complexes from high-salt wastewater. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1731-1742. doi: 10.11862/CJIC.20240077
-
[11]
Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
-
[12]
Peiran ZHAO , Yuqian LIU , Cheng HE , Chunying DUAN . A functionalized Eu3+ metal-organic framework for selective fluorescent detection of pyrene. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 713-724. doi: 10.11862/CJIC.20230355
-
[13]
Di WU , Ruimeng SHI , Zhaoyang WANG , Yuehua SHI , Fan YANG , Leyong ZENG . Construction of pH/photothermal dual-responsive delivery nanosystem for combination therapy of drug-resistant bladder cancer cell. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1679-1688. doi: 10.11862/CJIC.20240135
-
[14]
Chunmei GUO , Weihan YIN , Jingyi SHI , Jianhang ZHAO , Ying CHEN , Quli FAN . Facile construction and peroxidase-like activity of single-atom platinum nanozyme. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1633-1639. doi: 10.11862/CJIC.20240162
-
[15]
Xin XIONG , Qian CHEN , Quan XIE . First principles study of the photoelectric properties and magnetism of La and Yb doped AlN. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1519-1527. doi: 10.11862/CJIC.20240064
-
[16]
Xinyu ZENG , Guhua TANG , Jianming OUYANG . Inhibitory effect of Desmodium styracifolium polysaccharides with different content of carboxyl groups on the growth, aggregation and cell adhesion of calcium oxalate crystals. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1563-1576. doi: 10.11862/CJIC.20230374
-
[17]
Xiaoling LUO , Pintian ZOU , Xiaoyan WANG , Zheng LIU , Xiangfei KONG , Qun TANG , Sheng WANG . Synthesis, crystal structures, and properties of lanthanide metal-organic frameworks based on 2, 5-dibromoterephthalic acid ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1143-1150. doi: 10.11862/CJIC.20230271
-
[18]
Youlin SI , Shuquan SUN , Junsong YANG , Zijun BIE , Yan CHEN , Li LUO . Synthesis and adsorption properties of Zn(Ⅱ) metal-organic framework based on 3, 3', 5, 5'-tetraimidazolyl biphenyl ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1755-1762. doi: 10.11862/CJIC.20240061
-
[19]
Jiakun BAI , Ting XU , Lu ZHANG , Jiang PENG , Yuqiang LI , Junhui JIA . A red-emitting fluorescent probe with a large Stokes shift for selective detection of hypochlorous acid. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1095-1104. doi: 10.11862/CJIC.20240002
-
[20]
Jiaqi AN , Yunle LIU , Jianxuan SHANG , Yan GUO , Ce LIU , Fanlong ZENG , Anyang LI , Wenyuan WANG . Reactivity of extremely bulky silylaminogermylene chloride and bonding analysis of a cubic tetragermylene. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1511-1518. doi: 10.11862/CJIC.20240072
-
[1]
Metrics
- PDF Downloads(0)
- Abstract views(501)
- HTML views(87)