Citation: HAN Xue-Feng, CAI Hong-Xin, JIA Lei, WU Wei-Na, ZHANG Xin, XU Jun, ZHANG Zhao-Po, WANG Yuan. Syntheses, Characterizations and Antitumor Activities of Two Copper(Ⅱ) Complexes with an Acylhydrazone Ligand Bearing Pyrrole Unit[J]. Chinese Journal of Inorganic Chemistry, ;2015, 31(7): 1453-1459. doi: 10.11862/CJIC.2015.188 shu

Syntheses, Characterizations and Antitumor Activities of Two Copper(Ⅱ) Complexes with an Acylhydrazone Ligand Bearing Pyrrole Unit

HAN Xue-Feng ¹ ,
CAI Hong-Xin ² ,
JIA Lei ^2,, ,
WU Wei-Na ^2,, ,
ZHANG Xin ³ ,
XU Jun ² ,
ZHANG Zhao-Po ² ,
WANG Yuan ²

1.
1 Department of Personnel, Henan Polytechnic University, Jiaozuo, Henan 454000, China;
2.
2 Department of Physics and Chemistry, Henan Polytechnic University, Jiaozuo, Henan 454000, China;
3.
3 College of Agricultural and Biotechnology, China Agriculture University, Beijing 100083, China

Corresponding author: JIA Lei, WU Wei-Na,
Received Date: 1 April 2015
Available Online: 12 May 2015
Fund Project: 国家自然科学基金(No.21404033, 21401046, 21001040) (No.21404033, 21401046, 21001040)河南省教育厅自然科学基金(No.12B150011, 14B150029) (No.12B150011, 14B150029) 河南理工大学博士基金 (No.72515/086, 61307/003) 和江苏省自然科学基金(No. BK20141122)资助项目。 (No.72515/086, 61307/003) 和江苏省自然科学基金(No. BK20141122)

Two interesting copper(Ⅱ) complexes,[Cu(H₂L)₂(THF)] (1) and[Cu₂(L)Cl(CH₃OH)]·H₂O (2) based on H₃L {ethyl 5-[(2-hydroxyl-4-methylbenzoyl)amino-iminomethyl]-3,4-dimethyl-pyrrole-2-carboxylate} were synthesized and characterized by X-ray diffraction analyses. The results show that in complex 1, the copper(Ⅱ) ion is surrounded by two mono-deprotonated acylhydrazone ligands with NO donor sets and one THF molecule, and thus possesses a distorted square pyramidal geometry. However, in binuclear complex 2, the acylhydrazone ligand is tri-deprotonated and bridges two copper(Ⅱ) ions with square-planar coordination geometry through NO and N₂O₂ atom sets, respectively. Both complexes have excellent antitumor activities towards A549, ECA109 and SGC7901 cancer cells.
- acylhydrazone;Cu(Ⅱ) complex;pyrrole;antitumor activity
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