Citation: OU Zhi-Bin, HUANG Shan-Hua, FU Xia-Bing, ZHU Li, LE Xue-Yi. Structure, Antibacterial Activities and DNA Interaction of a Copper(Ⅱ) Complex Derived from 2,4-Diamino-6-(2’-pyridyl)-1,3,5-triazine[J]. Chinese Journal of Inorganic Chemistry, ;2014, 30(5): 1017-1024. doi: 10.11862/CJIC.2014.177
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Acopper(Ⅱ) complex: [Cu(H2O)(PyTA)2](ClO4)2[PyTA=2,4-diamino-6-(2'-pyridyl)-1,3,5-triazine], was synthesized and characterized by elemental analysis, molar conductivity, IR, UV-Vis and single crystal X-ray diffraction. The crystal belongs to monoclinic, space group P21/c, with the crystal cell parameters: a=0.98024(6) nm, b=1.24831(7) nm, c=2.15727(11) nm; β=108.657(3)°; Z=4, V=2.5010(2) nm3, R1=0.0543, wR2=0.1506. The complex was assayed against gram-positive (S.aureus, B. subtilis, B. thuringiensis) and gram-negative (X. oryzae, Salmonella, E. coil)bacteria by doubling dilutions method, and the interaction of the complex to DNA was investigated by electronic absorption, fluorescence, viscosity measurement and agarose gel electrophoresis assay. The results showed that the complex has good antibacterial activities, and could bind to CT-DNA by an intercalative mode, and cleave pBR322 DNAby hydroxyl radicals as the active species in the presence of Vit C.
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