A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation

M. Nibin Joy Bhaskaran Savitha Ayyiliyath M. Sajith Yadav D. Bodke Talavara Venkatesh K. K. Abdul Khader M. Syed Ali Padusha A. Muralidharan

Citation:  M. Nibin Joy, Bhaskaran Savitha, Ayyiliyath M. Sajith, Yadav D. Bodke, Talavara Venkatesh, K. K. Abdul Khader, M. Syed Ali Padusha, A. Muralidharan. A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation[J]. Chinese Chemical Letters, 2016, 27(01): 31-36. doi: 10.1016/j.cclet.2015.08.015 shu

A facile access for the synthesis of some C-2 substituted imidazopyrazines by utilizing the palladium catalyzed Suzuki cross-coupling reaction under microwave irradiation

    通讯作者: Ayyiliyath M. Sajith,
    Yadav D. Bodke,
摘要: A rapid, efficient, and facile synthesis of an assortment of C-2 substituted imidazopyrazines has been achieved by utilizing the palladium catalyzed Suzuki cross-coupling of 2-bromo-1H-imidazo[4,5-b]pyrazine with various boronic acids under microwave irradiation. The utilization of(A-taphos)2PdCl2 as a catalyst in combination with CsF as base and DME-H2O(4:1) as the solvent system at 100℃ procured the diaryls in acceptable to excellent yields. Prominent features of this developed methodology include short reaction times, fewer side products, and exceptional tolerance to a wide variety of functional groups.

English

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  • 发布日期:  2015-08-31
  • 收稿日期:  2015-06-25
  • 网络出版日期:  2015-08-03
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